Journal
NANOSCALE
Volume 6, Issue 3, Pages 1445-1452Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr04255c
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Funding
- National Basic Research Program of China [2011CB936004, 2012CB720602]
- National Natural Science Foundation of China [21072182, 91213302, 21210002]
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A simple and green strategy has been reported for the first time to fabricate upconversion nanoparticles (UCNPs) by utilizing nucleotides as bio-templates. The influence of the functionalities present on the nucleotide on the production of nanoparticles was investigated in detail. Through the effects of nucleotides, the obtained nanoparticles possessed a porous structure. The use of the as-prepared UCNPs for cell imaging, drug delivery and versatile therapy applications were demonstrated. In view of the bright up-conversion luminescence as well as the excellent biocompatibility, and the good colloidal stability of the as-prepared UCNPs, we envision that our synthesis protocol might advance both the fields of UCNPs and biomolecule-based nanotechnology for future studies.
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