Journal
NANOSCALE
Volume 5, Issue 12, Pages 5262-5265Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr01289a
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Funding
- MOST [2009CB930001, 2011CB933201, 2012AA030308, 2011CB707604]
- NSFC [51105086, 21025520, 51073045, 11272321]
- CAS [KJCX2-YW-M15, KJCX2-YW-H18]
- [SKLEAC201207]
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This report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of similar to 100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease.
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