4.8 Review

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

Journal

NANOSCALE
Volume 5, Issue 18, Pages 8307-8325

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr01525d

Keywords

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Funding

  1. State High-Tech Development Plan [2012AA020804]
  2. National Natural Science Foundation of China [30970784, 81171455]
  3. National Key Basic Research Program of China (MOST 973 project) [2009CB930200]
  4. National Distinguished Young Scholars grant from the National Natural Science Foundation of China [31225009]
  5. Chinese Academy of Sciences (CAS) Hundred Talents Program [07165111ZX]
  6. CAS Knowledge Innovation Program
  7. NIH/NIMHD [8 G12 MD007597]
  8. USAMRMC [W81XWH-10-1-0767]
  9. National Institute on Minority Health and Health Disparities [G12MD007597] Funding Source: NIH RePORTER

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The advent of nanotechnology has reignited interest in the field of pharmaceutical science for the development of nanomedicine. Nanomedicinal formulations are nanometer-sized carrier materials designed for increasing the drug tissue bioavailability, thereby improving the treatment of systemically applied chemotherapeutic drugs. Nanomedicine is a new approach to deliver the pharmaceuticals through different routes of administration with safer and more effective therapies compared to conventional methods. To date, various kinds of nanomaterials have been developed over the years to make delivery systems more effective for the treatment of various diseases. Even though nanomaterials have significant advantages due to their unique nanoscale properties, there are still significant challenges in the improvement and development of nanoformulations with composites and other materials. Here in this review, we highlight the nanomedicinal formulations aiming to improve the balance between the efficacy and the toxicity of therapeutic interventions through different routes of administration and how to design nanomedicine for safer and more effective ways to improve the treatment quality. We also emphasize the environmental and health prospects of nanomaterials for human health care.

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