Journal
NANOSCALE
Volume 5, Issue 21, Pages 10127-10140Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr03633b
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Funding
- National Institutes of Health [RO1 341 EB006201]
- Department of Defense (DOD) [W81XWH-09-1-0064]
- Defense Advanced Research Projects Agency [HR0011-13-2-0003]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006201] Funding Source: NIH RePORTER
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This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of combining spectral selectivity and high sensitivity of the surface-enhanced Raman scattering (SERS) process with the inherent molecular specificity of nanoprobes provides an important multiplex diagnostic modality. Gold nanostars can provide an excellent multi-modality platform, combining two-photon luminescence with photothermal therapy as well as Raman imaging with photodynamic therapy. Several examples of optical detection using SERS and photonics-based treatments are presented to illustrate the usefulness and potential of the plasmonic nanoprobes for theranostics, which seamlessly combines diagnostics and therapy.
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