Journal
NANOSCALE
Volume 5, Issue 5, Pages 2065-2072Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2nr33685e
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Funding
- Natural Science Foundation of China [21074045]
- 973 Project [2009CB623605]
- Project of Jilin Province [20100704]
- Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University
- College of Animal Science and Veterinary Medicine, Jilin University
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Fluorescent nanoparticles (FNPs) have been found to be useful as visualization tools for biological sensing, probing, imaging, and monitoring. Applied to targeted cancer cell imaging, FNPs are highly desirable for early stage cancer diagnosis and treatment. However, the light emission from most of the FNPs reported is severely limited because of the aggregation-caused quenching (ACQ) effect. Herein, we present highly emissive inorganic-organic nanoparticles with core-shell structures for targeted cancer cell imaging. Coated with a folate-functionalized silica shell, 9,10-distyrylanthracene (DSA) fluorogens with aggregation-induced emission (AIE) properties served as the fluorescent core, affording folate-functionalized fluorescent silica nanoparticles (FFSNPs) with a high fluorescence quantum yield (up to 20%). The FFSNPs are of small size (diameter similar to 60 nm), monodispersed, stable in aqueous suspension, and pose little toxicity to living cells and thus can be utilized for targeted HeLa cell imaging. In addition, the FFSNPs are mesoporous and therefore can potentially be used as vehicles for controlled, externally activated release of anticancer drugs.
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