Journal
NANOSCALE
Volume 5, Issue 19, Pages 8973-8976Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr03006g
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Funding
- School of Materials Science and Engineering, Nanyang Technological University, Singapore
- Provost Office, Nanyang Technological University, Singapore
- Swedish Foundation for Strategic Research (SSF)
- Knut and Alice Wallenberg Foundation (KAW), CeNano
- Swedish Research Council (VR)
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A peptide with two cleavage sites for MMP-7 has been synthesized and immobilized on gold nanoparticles (AuNPs) through a cysteine residue. Digestion of the peptide by MMP-7 decreases its size and net charge, which leads to the aggregation of the AuNPs. The color shift caused by aggregation enables a direct and quantitative measurement of the concentration and activity of MMP-7 with an estimated limit of detection of similar to 5 nM (0.1 mu g mL(-1)).
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