4.8 Article

FITC-quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells

Journal

NANOSCALE
Volume 5, Issue 19, Pages 8963-8967

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr03339b

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Funding

  1. National Natural Science Foundation of China [21175122, 91127036]
  2. Fundamental Research Funds for Central Universities [WK2060190018]

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By employing fluorescence resonance energy transfer (FRET) quenching, we rationally designed two new FITC-quencher based nanoprobes for effectively sensing caspase 3 (Casp3) in vitro and in cells. Our nanoprobes hold promise for assessing the chemotherapeutic effect of cancer treatment.

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