Journal
NANOSCALE
Volume 5, Issue 14, Pages 6249-6253Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr00227f
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Funding
- Beijing area major laboratory of peptide and small molecular drugs
- PHR (IHLB)
- NSFC [21171120, 81172930]
- Beijing Natural Science Foundation [7132020]
- Project for Science and Technology Development, Beijing Commission of Education [SQKM201210025007]
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Mesoporous silica nanoparticles with amino and thiol groups (MSNSN) were prepared and covalently modified with methotrexate and 6-mercaptopurine to form 6-MP-MSNSN-MTX. In the presence of DTT, 6-MP-MSNSN-MTX gradually releases 6-MP. In rat plasma, 6-MP-MSNSN-MTX effectively inhibits the metabolic deactivation of 6-MP and MTX. 6-MP-MSNSN-MTX could be an agent for long-acting chemotherapy.
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