Journal
NANOSCALE
Volume 4, Issue 18, Pages 5686-5693Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2nr30731f
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Funding
- National Science and Technology Major Project [2011ZX09102-001-10]
- Sichuan Key Technology RD Program [2011SZ0219]
- New Century Excellent Talents in University [NCET-08-0371]
- National Natural Science Foundation [NSFC81071864]
- Chinese Key Basic Research Program [2010CB529906]
- National Science and Technology Major Project [2011ZX09102-001-10]
- Sichuan Key Technology RD Program [2011SZ0219]
- New Century Excellent Talents in University [NCET-08-0371]
- National Natural Science Foundation [NSFC81071864]
- Chinese Key Basic Research Program [2010CB529906]
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Many drug delivery systems (DDSs) have been investigated for local targeting of malignant disease with the intention of increasing anti-tumor activity and minimizing systemic toxicity. An injectable thermosensitive hydrogel was applied to prevent locoregional recurrence of 4T1 breast cancer in a mouse model. The presented hydrogel, which is based on poly(ethyleneglycol)-poly(epsilon-caprolactone)poly( ethylene glycol) (PEG-PCL-PEG, PECE), flows freely at normal temperature, forms a gel within seconds in situ at body temperature, and eventually releases the drug in a consistent and sustained fashion as it gradually biodegrades. Locoregional recurrence after primary tumor removal was significantly inhibited in mice treated with the paclitaxel (PTX)-loaded PECE hydrogel subcutaneously (9.1%) administered, compared with the blank hydrogel (80.0%), systemic (77.8%) and locally (75.0%) administered PTX, and the control group (100%) (P < 0.01). In addition, tensile strength measurements of the surgical incisions showed that the PECE hydrogel accelerates wound healing at postoperative day 7 (P < 0.05), and days 4 and 14 (P > 0.05), in agreement with histopathological examinations. This novel DDSs represents a promising approach for local adjuvant therapy in malignant disease.
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