4.8 Article

In situ synthesis of porous silica nanoparticles for covalent immobilization of enzymes

Journal

NANOSCALE
Volume 4, Issue 2, Pages 414-416

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nr11153a

Keywords

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Funding

  1. National Basic Research Program of China [2009CB930200, 2011CB933402]
  2. China Natural Science Foundation [21073117, 21071094]
  3. Ministry of Education of China [2011053]
  4. Shanghai Municipal Education Committee [11ZZ82]
  5. Shanghai Leading Academic Disciplines [S30109]

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A simple method is used to covalently encapsulate enzymes in silica nanoparticles. The encapsulation is highlighted by the high enzyme loading and porous channels that provide efficient diffusion for small substrate and product molecules while preventing protease degradation.

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