Journal
NANOSCALE
Volume 4, Issue 1, Pages 298-302Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nr11285f
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Funding
- Universidad Autonoma de Madrid
- Spanish Ministerio de Educacion y Ciencia [MAT 2010-16116]
- Banco Santander CEAL-UAM
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Concordia University Research Chairs
- Comunidad Autonoma de Madrid [CCG087-UAM/MAT-4434, S2009/MAT-1756]
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A new approach to deep tissue imaging is presented based on 8 nm CdTe semiconductor quantum dots (QDs). The characteristic 800 nm emission was found to be efficiently excited via two-photon absorption of 900 nm photons. The fact that both excitation and emission wavelengths lie within the biological window allows for high resolution fluorescence imaging at depths close to 2 mm. These penetration depths have been used to obtain the first deep tissue multiphoton excited fluorescence image based on CdTe-QDs. Due to the large thermal sensitivity of CdTe-QDs, one may envisage, in the near future, their use in high resolution deep-tissue thermal imaging.
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