Journal
NANOSCALE
Volume 4, Issue 3, Pages 879-884Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2nr11407k
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Funding
- Natural Science Foundation of China [NSFC21073091]
- Natural Science Foundation of Jiangsu Province [BK2009225]
- National Basic Research Program of China [2007CB925102]
- Fundamental Research Funds for the Central Universities [1105020505, 1116020505]
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Bifunctional bacterial magnetic nanoparticles (BBMPs), which present both magnetic drug targeting and tumor bio-targeting properties, have been developed by chemically coupling both doxorubicin and a galactosyl ligand on to the membrane surface of the bacterial magnetic nanoparticles (BMPs). The BBMP product has a high drug load ratio and magnetic respondence, and exhibits a narrow size distribution and is sensitive to pH to enable drug release. In comparison to doxorubicin-coupled BMPs, without modification with a galactosyl ligand, BBMPs present a higher uptake by the target asialoglycoprotein receptor (ASGP-R) expressed by HepG2 cells and display stronger cytotoxicity.
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