Journal
NANOSCALE
Volume 3, Issue 5, Pages 1974-1976Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0nr00956c
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Funding
- National Basic Research Program of China (973 Program) [2009CB930200, 2011CB933402]
- China Natural Science Foundation [21073117, 21071094]
- Shanghai Municipal Education Committee [11ZZ82]
- Shanghai Leading Academic Disciplines [S30109]
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The enhanced green fluorescence protein (EGFP) is efficiently encapsulated in silica nanoparticle by multiple covalent bonds. The silica encapsulation greatly increases EGFP's fluorescence intensity and stabilities against protease, denaturant and heat, making it a potential fluorescence probe for cellular imaging.
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