Journal
NANOSCALE
Volume 3, Issue 4, Pages 1451-1455Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0nr00834f
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Funding
- NSF [CHE-0547846]
- NSF/EPSCoR [2001RII-EPS-0132573, 2004RII-EPS-0447660]
- Direct For Mathematical & Physical Scien [1058885] Funding Source: National Science Foundation
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We report a novel nanoparticle that is promising for photodynamic therapy applications, which consists of a pi-conjugated polymer doped with a singlet oxygen photosensitizer. The nanoparticles exhibit highly efficient collection of excitation light due to the large excitation cross-section of the polymer. A quantum efficiency of singlet oxygen production of 0.5 was determined. Extraordinarily large two-photon excitation cross-sections were determined, indicating promise for near infrared multiphoton photodynamic therapy. Gel electrophoresis of DNA after near-UV irradiation in the presence of nanoparticles indicated both purine base and backbone DNA damage.
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