4.8 Article

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

Journal

NANOSCALE
Volume 3, Issue 12, Pages 4943-4945

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nr11242b

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Funding

  1. National Institute of Biomedical Imaging and Bioengineering (NIBIB), NCI R00 [CA153772]
  2. National Nature Science of Foundation of China (NSFC) [51172005, 81028009]
  3. National Basic Research Program of China [2010CB934602]
  4. China Scholarship Council
  5. NATIONAL CANCER INSTITUTE [R00CA153772] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZIAEB000083] Funding Source: NIH RePORTER
  7. CLINICAL CENTER [ZICCL040013] Funding Source: NIH RePORTER

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We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.

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