Journal
NANOSCALE
Volume 2, Issue 6, Pages 1021-1026Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b9nr00401g
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Funding
- National Natural Science Foundation [20704043, 20805055, 20873175]
- Shanghai Municipal Commission for Science and Technology [08QA14078, 0952nm04600]
- Ministry of Health [2009ZX10004-301]
- K. C. Wong education foundation, Hong Kong
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In this work, we report the design of a novel graphene-based molecular beacon (MB) that could sensitively and selectively detect specific DNA sequences. The ability of water-soluble graphene oxide (GO) to differentiated hairpin and dsDNA offered a new approach to detect DNA. We found that the background fluorescence of MB was significantly suppressed in the presence of GO, which increased the signal-to-background ratio, hence the sensitivity. Moreover, the single-mismatch differentiation ability of hairpin DNA was maintained, leading to high selectivity of this new method.
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