Journal
NANOSCALE
Volume 2, Issue 4, Pages 548-558Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b9nr00304e
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Funding
- National Institutes of Health [HL080729, 1R01EB008111]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL080729] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB008111] Funding Source: NIH RePORTER
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Fluorescent cross-linked nanoparticles with variable fluorophore loading amounts, locations, and particle sizes were synthesized from sequential one-pot functionalization/cross-linking of block copolymer micelles with amine-terminated dye and cross-linker molecules, via reductive amination and amidation. The fluorescence quantum yield and brightness of these nanoparticles were evaluated by steady-state and dynamic fluorescence methods. The results demonstrate that the quantum yield and brightness of the fluorescent nanoparticles correlated directly with the number of dyes/nanoparticle and the nanoparticle size. A strategy to increase the fluorescence brightness of nanoparticles with fluorescein and near-infrared dyes is proposed.
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