Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 10, Issue 5, Pages 949-958Publisher
ELSEVIER
DOI: 10.1016/j.nano.2014.01.010
Keywords
Stem cell; Polyurethane; Scaffold; Surface modification
Funding
- Vinnova program on Nanoscaffolds for control of stem cell division, differentiation and migration [2009-00227]
- Chinese National Science Foundation [51272153]
- Swedish Medical Research Council [2011-3113]
- Wilhelm and Martina Lundgren Fonden
- Rune och Ulla Amlovs stiftelse
- Stiftelsen Edit Jacobsons Donationsfond
- [ALFGBG-146341]
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The topographical effects from functional materials on stem cell behavior are currently of interest in tissue engineering and regenerative medicine. Here we investigate the influence of argon, oxygen, and hydrogen plasma surface modification of electrospun polyurethane fibers on human embryonic stem cell (hESC) and rat postnatal neural stem cell (NSC) responses. The plasma gases were found to induce three combinations of fiber surface functionalities and roughness textures. On randomly oriented fibers, plasma treatments lead to substantially increased hESC attachment and proliferation as compared to native fibers. Argon plasma was found to induce the most optimal combination of surface functionality and roughness for cell expansion. Contact guided migration of cells and alignment of cell processes were observed on aligned fibers. Neuronal differentiation around 5% was found for all samples and was not significantly affected by the induced variations of surface functional group distribution or individual fiber topography. From the Clinical Editor: In this study the influence of argon, oxygen, and hydrogen plasma surface modification of electrospun polyurethane fibers on human embryonic stem cell and rat postnatal neural stem cell (NSC) responses is studied with the goal of clarifying the potential effects of functional materials on stem cell behavior, a topic of substantial interest in tissue engineering and regenerative medicine. (C) 2014 Elsevier Inc. All rights reserved.
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