Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 10, Issue 2, Pages 401-409Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2013.08.003
Keywords
Nanoparticles; Nanoprecipitation; 3D flow focusing; Microfluidics; Block copolymers
Funding
- Koch-Prostate Cancer Foundation Award in Nanotherapeutics
- Dana Farber Cancer Institute Prostate SPORE [5P50CA090381-09]
- NIH [EB015419, CA119349, EB003647]
- National Cancer Institute Center of Cancer Nanotechnology Excellence at MIT-Harvard [U54-CA151884]
- National Research Foundation of Korea (NRF) [2012-K1A1A2048701]
- Canadian Institute of Health Research (CIHR)
- NSF Graduate Research Fellowship
- National Research Foundation of Korea [2012K1A1A2045436] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Microfluidic synthesis of nanoparticles (NPs) can enhance the controllability and reproducibility in physicochemical properties of NPs compared to bulk synthesis methods. However, applications of microfluidic synthesis are typically limited to in vitro studies due to low production rates. Herein, we report the parallelization of NP synthesis by 3D hydrodynamic flow focusing (HFF) using a multilayer microfluidic system to enhance the production rate without losing the advantages of reproducibility, controllability, and robustness. Using parallel 3D HFF, polymeric poly(lactide-co-glycolide)-b-polyethyleneglycol (PLGA-PEG) NPs with sizes tunable in the range of 13-150 nm could be synthesized reproducibly with high production rate. As a proof of concept, we used this system to perform in vivo pharmacokinetic and biodistribution study of small (20 nm diameter) PLGA-PEG NPs that are otherwise difficult to synthesize. Microfluidic parallelization thus enables synthesis of NPs with tunable properties with production rates suitable for both in vitro and in vivo studies. (C) 2014 Elsevier Inc. All rights reserved.
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