Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 9, Issue 7, Pages 895-902Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2013.01.013
Keywords
Layer-by-layer; Protein encapsulation; Drug delivery; Tissue engineering; Biomaterials
Funding
- EU 7th Framework Programme [NMP4-SL-2009-229292]
- Fundacao para a Ciencia e Tecnologia (FCT) from Portugal [SFRH/BD/61126/2009, SFRH/BD/61390/2009]
- Fundo Social Europeu-FSE, Programa Diferencial de Potencial Humano-POPH
- MICINN [MAT 2009 14195-C03 03, ACI2009-0890, MAT2010-15310, MAT2010-15982, PRI-PIBAR-2011-1403]
- JCyL [VA049A11, VA152A12, VA155A12]
- CIBER-BBN. E.C
- Fundação para a Ciência e a Tecnologia [SFRH/BD/61126/2009, SFRH/BD/61390/2009] Funding Source: FCT
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Multilayer capsules conceived at the nano-and microscales are receiving increasing interest due to their potential role as carriers of biomolecules for drug delivery and tissue engineering. Herein we report the construction of microcapsules by the sequential adsorption of chitosan and a biomimetic elastin-like recombinamer into nanostructured layers on inorganic microparticle templates. The release profile of bovine serum albumin, which was studied at 25 and 37 degrees C, shows higher retention and Fickian diffusion at physiological temperature. The self-assembled multilayers act as a barrier and allowed for sustained release over 14 days. The capsules studied are non-cytotoxic towards L929 cells, thereby suggesting multiple applications in the fields of biotechnology and bioengineering, where high control of the delivery of therapeutics and growth/differentiation factors is required.
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