Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 8, Issue 5, Pages 599-608Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2011.08.005
Keywords
Cerium oxide; Nanoceria; Nanoparticles; Neuronal cells; Genomics
Funding
- National Institutes of Health (NIH)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- MRSEC of National Science Foundation [DMR-0213574]
- Department of Energy (DOE) [DE FG02-05ER15730]
- U.S. Department of Energy (DOE) [DE-FG02-05ER15730] Funding Source: U.S. Department of Energy (DOE)
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Cerium oxide nanoparticles (nanoceria) are engineered nanoparticles whose versatility is due to their unique redox properties. We and others have demonstrated that naked nanoceria can act as antioxidants to protect cells against oxidative damage. Although the redox properties may be beneficial, the genome-wide effects of nanoceria on gene transcription and associated biological processes remain elusive. Here we applied a functional genomic approach to examine the genome-wide effects of nanoceria on global gene transcription and cellular functions in mouse neuronal cells. Importantly, we demonstrated that nanoceria induced chemical- and size-specific changes in the murine neuronal cell transcriptome. The nanoceria contributed more than 83% of the population of uniquely altered genes and were associated with a unique spectrum of genes related to neurological disease, cell cycle control, and growth. These observations suggest that an in-depth assessment of potential health effects of naked nanoceria and other naked nanoparticles is both necessary and imminent.
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