Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 8, Issue 8, Pages 1372-1378Publisher
ELSEVIER
DOI: 10.1016/j.nano.2012.03.005
Keywords
Dendrimer; Alzheimer's disease; A beta 1-28; Amyloid peptide
Funding
- project Biological Properties and Biomedical Applications of Dendrimers
- European Regional Development Fund
- Spanish MICINN [CTQ2009-10963, CTQ2009-14146-C02-02]
- Xunta de Galicia [10CSA209021PR, CN2011/037]
- Spanish Ministry of Education
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The influence of a GATG (gallic acid-triethylene glycol) dendrimer decorated with 27 terminal morpholine groups ([G3]-Mor) on the aggregation process of Alzheimer's peptide has been investigated. Amyloid fibrils were formed from the A beta 1-28 peptide and the process was monitored by a ThT assay, changes in CD spectra, and transmission electron microscopy. In the presence of [G3]-Mor, more fibrils were built and the process significantly accelerated compared with a control. The cytotoxicity of (1) A beta and (2) the system [G3]-Mor/A beta was monitored at different stages of the aggregation process. Prefibrillar species were more toxic than mature fibrils. [G3]-Mor significantly reduced the toxicity of A beta, probably because of lowering the amount of prefibrillar forms in the system by speeding up the process of fibril formation.
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