Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 8, Issue 7, Pages 1070-1073Publisher
ELSEVIER
DOI: 10.1016/j.nano.2012.05.014
Keywords
Hyaluronic acid; Quantum dots; Confocal microscopy; Bioimaging; Drug delivery
Funding
- Convergence Research Center Program
- Mid-career Researcher Program
- National Research Foundation (NRF) of Korea
- Ministry of Education, Science and Technology [2009-0081871, 2009-0084578, R31-2008-000-10071-0]
- National Research Foundation of Korea [2009-0084578, 2010-50196, R31-2012-000-10071-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hyaluronic acid (HA), which is a biocompatible, biodegradable, and linear polysaccharide in the body, has been widely used for various biomedical applications. In this work, real-time bioimaging for target-specific delivery of HA derivatives was carried out using quantum dots (QDs). In vitro confocal microscopy of HA-QD conjugates confirmed the intracellular delivery of HA derivatives to B16F1 cells with HA receptors by HA-receptor-mediated endocytosis. Furthermore in vivo real-time confocal microscopy of HA-QD conjugates successfully visualized the target specific delivery and accumulation of HA-QD conjugates from the fluorescence-labeled blood vessels to the liver tissues. The authors could confirm the feasibility of HA derivatives as a target-specific intracellular drug-delivery carrier for the treatment of liver diseases and the in vivo real-time confocal microscopy as a new bioimaging tool for various drug-delivery applications. From the Clinical Editor: This study demonstrates the possibility of labeling hyaluronic acid with quantum dots for visualization and for targeted intracellular drug delivery in liver disease models. (C) 2012 Elsevier Inc. All rights reserved.
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