Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 7, Issue 6, Pages 797-805Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2011.02.007
Keywords
Magnetoliposome; SPIO nanoparticle; Folate receptor; PEG-lipid
Funding
- National Science Foundation (NSF) [CBET-0931875]
- Rhode Island Foundation [20070262]
- RI-INBRE from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [P20RR016457]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0931875] Funding Source: National Science Foundation
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Folate-targeted cationic magnetoliposomes (FTMLs) have been prepared with coencapsulated doxorubicin (DOX) and anionic superparamagnetic iron oxide (SPIO) nanoparticles (NPs) with 5 nm gamma-Fe2O3 cores and 16 nm hydrodynamic diameters. NP encapsulation (89%) was confirmed by cryogenic transmission electron microscopy (TEM), and the presence of the oppositely charged NPs did not cause liposome aggregation. The FTMLs had an average diameter of 174 +/- 53 nm and existed as unilamellar and cup-shaped liposomes, which was attributed to dissimilar lipid packing parameters and the presence of PEG-lipids. A 3-fold increase in DOX release was achieved over 2 hours when the encapsulated SPIO NPs were heated by an alternating current electromagnetic field operating at radio frequencies (RF). Results with human cervical cancer cells (HeLa), which have been shown to exhibit high folate receptor (FR) expression, confirmed FTML surface binding and cellular uptake. In contrast, no uptake was observed for lower FR-expressing human breast carcinoma cells (ZR-75-1). From the Clinical Editor: This study discusses the design and cellular uptake of multifunctional folate-targeted cationic magnetoliposomes enabling doxorubicin delivery and SPIO labeling. (C) 2011 Elsevier Inc. All rights reserved.
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