Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 6, Issue 5, Pages 634-641Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2010.04.005
Keywords
Viral nanoparticles; Nanomedicine; Imaging; Drug-delivery
Funding
- American Heart Association
- National Institutes of Health [K99 EB009105]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [K99EB009105] Funding Source: NIH RePORTER
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Nanomaterials have been developed for potential applications in biomedicine, such as tissue-specific imaging and drug delivery. There are many different platforms under development, each with advantages and disadvantages, but viral nanoparticles (VNPs) are particularly attractive because they are naturally occurring nanomaterials, and as such they are both biocompatible and biodegradable. VNPs can be designed and engineered using both genetic and chemical protocols. The use of VNPs has evolved rapidly since their introduction 20 years ago, encompassing numerous chemistries and modification strategies that allow the functionalization of VNPs with imaging reagents, targeting ligands, and therapeutic molecules. This review discusses recent advances in the design of smart targeted VNPs for therapeutic and imaging applications.
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