Journal
NANOMEDICINE
Volume 9, Issue 7, Pages 1047-1062Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.59
Keywords
cellular temperature; fluorescent nanoparticle; nanotechnology; nanothermometry; single cell
Funding
- Universidad Autonoma de Madrid
- Comunidad Autonoma de Madrid [S2009/MAT-1756]
- Spanish Ministerio de Educacion y Ciencia [MAT2010-16161]
- Spanish Ministerio de Economia y Competitividad (MINECO)
- Ministerio de Economia y Competitividad de Espana
- European Commission [FP7-PEOPLE-2010-IOF-274404]
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The importance of high-resolution intracellular thermal sensing and imaging in the field of modern biomedicine has boosted the development of novel nanosized fluorescent systems (fluorescent nanothermometers) as the next generation of probes for intracellular thermal sensing and imaging. This thermal mapping requires fluorescent nanothermometers with good biocompatibility and high thermal sensitivity in order to obtain submicrometric and subdegree spatial and thermal resolutions, respectively. This review describes the different nanosized systems used up to now for intracellular thermal sensing and imaging. We also include the later advances in molecular systems based on fluorescent proteins for thermal mapping. A critical overview of the state of the art and the future perspective is also included.
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