Journal
NANOMEDICINE
Volume 9, Issue 4, Pages 501-516Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.14.5
Keywords
biocompatibility; drug targeting; magnetic hyperthermia; MRI; nanoparticle; targeted drug and gene delivery; tissue engineering
Funding
- NCRR NIH HHS [P30RR031151, P30 RR031151] Funding Source: Medline
- NIA NIH HHS [R01 AG043540] Funding Source: Medline
- NIDA NIH HHS [1P01DA028555, P01 DA028555] Funding Source: Medline
- NIMH NIH HHS [P01 MH064570, P01MH64570] Funding Source: Medline
- NINDS NIH HHS [2R01NS034239, 2R01NS36126, R01 NS034239, R37 NS036126, P01 NS043985, P01NS43985, R01 NS036126] Funding Source: Medline
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Magnetic nanoparticles (MNPs) are a new and promising addition to the spectrum of biomedicines. Their promise revolves around the broad versatility and biocompatibility of the MNPs and their unique physicochemical properties. Guided by applied external magnetic fields, MNPs represent a cutting-edge tool designed to improve diagnosis and therapy of a broad range of inflammatory, infectious, genetic and degenerative diseases. Magnetic hyperthermia, targeted drug and gene delivery, cell tracking, protein bioseparation and tissue engineering are but a few applications being developed for MNPs. MNPs toxicities linked to shape, size and surface chemistry are real and must be addressed before clinical use is realized. This article presents both the promise and perils of this new nanotechnology, with an eye towards opportunity in translational medical science.
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