Journal
NANOMEDICINE
Volume 9, Issue 16, Pages 2499-2509Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.26
Keywords
carbon nanotube; contrast agent; MRI; multimodal imaging; positron emission tomography
Funding
- Welch Foundation (Rice University [TX, USA]) [C-0627]
- National Science Foundation's Graduate Research Fellowship Program (Rice University) [0940902]
- NIH (University of Texas Health Science Center [USA]) [U54 CA136404]
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Aims: Simultaneous positron emission tomography/MRI has recently been introduced to the clinic and dual positron emission tomography/MRI probes are rare and of growing interest. We have developed a strategy for producing multimodal probes based on a carbon nanotube platform without the use of chelating ligands. Materials & methods: Gd3+ and Cu-64(2+) ions were loaded into ultra-short single-walled carbon nanotubes by sonication. Normal, tumor-free athymic nude mice were injected intravenously with the probe and imaged over 48 h. Results & conclusion: The probe was stable for up to 24 h when challenged with phosphate-buffered saline and mouse serum. Positron emission tomography imaging also confirmed the stability of the probe in vivo for up to 48 h. The probe was quickly cleared from circulation, with enhanced accumulation in the lungs. Stable encapsulation of contrast agents within ultra-short single-walled carbon nanotubes represents a new strategy for the design of advanced imaging probes with variable multimodal imaging capabilities.
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