Journal
NANOMEDICINE
Volume 9, Issue 5, Pages 723-740Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.8
Keywords
chitosan nanoformulations; drug delivery; internal stimuli-responsive; intracellular release; nondestructive pathways
Funding
- Independent Innovation Foundation of Shandong University, IIFSDU [2010JC018]
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The use of chitosan-based nanocarriers to transport active compounds gained an increasing attention in drug delivery. Intracellular delivery, with efficient intracellular release, become an important design considerations in chitosan based nanoformlations. Internal stimuli-responsive nanoformulations are designed to release active compounds after internalization based on certain internal stimuli like pH, redox potential and enzymes. Futhermore, nondestructive pathways may provide a nondigestive compartment for active compounds transport, which can protect the encapsulated agents from possible lysosomal degradation, thereby realizing release agents safely. This review gives a brief overview about the chitosan-based nanoformulations for efficient intracellular cargo release, including internal stimuli-responsive nanoformulations and nondestructive pathways based nanoformulations: design strategies and applications. The present problems and a possible future perspective related them are also discussed.
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