Journal
NANOMEDICINE
Volume 9, Issue 15, Pages 2387-2401Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.133
Keywords
cancer molecular imaging; dendritic nanoglobules; drug and gene delivery; gadolinium; manganese(II); MRI contrast agent; peptide-targeted; POSS dendrimer; tumor extracellular environment
Funding
- NCATS NIH HHS [UL1 TR000439] Funding Source: Medline
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Dendrimers have been recognized as promising materials for biomedical applications due to their unique properties, such as well-defined unimolecular structures, precise molecular weights and high degrees of branching and surface functionality. The dendrimers with a polyhedral oligomeric silsesquioxane core - nanoglobules - have many advantageous features over traditional dendrimers, including more functional groups at the same generation of dendrimers, well-defined 3D structures and relatively compact morphologies. Various nanoglobules of polyhedral oligomeric silsesquioxane-core dendrimers have been synthesized and investigated for biomedical applications. Nanoglobules have been used as carriers for developing drug-delivery systems, gene-delivery systems and imaging contrast agents with precisely defined structures and sizes. This article summarizes the recent developments in nanoglobules for biomedical applications.
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