Journal
NANOMEDICINE
Volume 9, Issue 5, Pages 667-693Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.14.32
Keywords
dendritic amphiphile; lipid; nonviral DNA/siRNA delivery; polyplex/lipoplex; responsive system; self-assembling dendrimer; transfection efficiency
Funding
- Biotransporter Project of the Bundesministerium fur Bildung und Forschung
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In this review, we outline the concept and applicability of self-assembling dendrimers for gene-delivery applications. Low-molecular-weight, well-defined cationic dendritic arrays which have been modified with hydrophobic domains can form self-organized multivalent systems that have significant advantages over nonassembling, high-molecular-weight/polymeric gene vectors. Particular structural variations have been highlighted with respect to the individual components of the displayed dendritic amphiphiles, namely, the employed amine termini, the hydrophobic segment, the size of the dendritic array, and the integration of special features such as targeting ability and cleavability/degradability, which can all have a crucial effect on gene-transfection efficiencies. Accordingly, the scientific efforts to create new synthetic gene-delivery vectors to act as promising in vivo transfection agents in the future will be presented and discussed here.
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