Journal
NANOMEDICINE
Volume 8, Issue 9, Pages 1459-1481Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.13.132
Keywords
design; electrospinning; nanofiber scaffold; orthopedic tissue; regeneration; repair; tissue engineering
Funding
- National Center for Research Resources [UL1RR033173]
- Office of the Director, NIH [1R15 AR063901-01]
- NIH roadmap for Medical Research
- Marshall Institute for Interdisciplinary Research
- Center for Diagnostic Nanosystems at Marshall University
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This article reviews recent significant advances in the design of nanofiber scaffolds for orthopedic tissue repair and regeneration. It begins with a brief introduction on the limitations of current approaches for orthopedic tissue repair and regeneration. It then illustrates that rationally designed scaffolds made up of electrospun nanofibers could be a promising solution to overcome the problems that current approaches encounter. The article also discusses the intriguing properties of electrospun nanofibers, including control of composition, structures, orders, alignments and mechanical properties, use as carriers for topical drug and/or gene sustained delivery, and serving as substrates for the regulation of cell behaviors, which could benefit musculoskeletal tissue repair and regeneration. It further highlights a few of the many recent applications of electrospun nanofiber scaffolds in repairing and regenerating various orthopedic tissues. Finally, the article concludes with perspectives on the challenges and future directions for better design, fabrication and utilization of nanofiber scaffolds for orthopedic tissue engineering.
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