Journal
NANOMEDICINE
Volume 6, Issue 3, Pages 519-528Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.11.16
Keywords
dual-mode probe; iron oxide nanoparticle; magnetic-fluorescent; MFe2O4; quantum dot
Funding
- Fonds de la Recherche Scientifique
- French Community of Belgium [05/10-335]
- European Community
- COST Action [D38]
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Magnetic iron oxide nanoparticles and their dispersion in various mediums are of wide interest for their biomedical applications and physicochemical properties. MFe2O4 or MOFe2O3 (where M = Co, Li, Ni or Mn, for example) can be molecularly engineered to provide a wide range of magnetic properties. In this article, we survey the literature, integrating the results of our work to give a rational view on the synthesis, physicochemical properties and applications of MFe2O4, especially for MRI. However, retrieving detailed biological information on a subcellular level is difficult, owing to the limited resolution and low sensitivity of the MRI technique. Thus, this article also concentrates on the development of a magnetic iron oxide nanoparticles/quantum dot hybrids, as a dual-mode magnetic-fluorescent probe. The synthesis and physicochemical properties of the magnetic iron oxide nanoparticles/quantum dot hybrids and, especially, its application as an M RI-fluorescent probe, will also be described.
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