Journal
NANOMEDICINE
Volume 5, Issue 3, Pages 485-505Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.10
Keywords
drug delivery; micelles; nanotechnology; sustained delivery
Funding
- NATIONAL EYE INSTITUTE [R24EY017045, RC1EY020361] Funding Source: NIH RePORTER
- NEI NIH HHS [R24 EY017045-05, RC1 EY020361, RC1 EY020361-02] Funding Source: Medline
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Mice liar delivery systems smaller than 100 nm can be readily prepared. While micelles allow a great depth of tissue penetration for targeted drug delivery, they usually disintegrate rapidly in the body. Thus, sustained drug delivery from micellar nanocarriers is a challenge. This article summarizes various key strategies and underlying principles for sustained drug delivery using micellar nanocarriers. Comparisons are made with other competing delivery systems such as polymeric microparticles and nanoparticles. Amphiphilic molecules self-assemble in appropriate liquid media to form nanoscale micelles. Strategies for sustained release nanomicellar carriers include use of prodrugs, drug polymer conjugates, novel polymers with low critical micellar concentration or of a reverse thermoresponsive nature, reverse micelles, multi-layer micelles with layer by layer assembly, polymeric films capable of forming micelles in vivo and micelle coats on a solid support. These new micellar systems are promising for sustained drug delivery.
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