Journal
NANOMEDICINE
Volume 5, Issue 10, Pages 1585-1593Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.92
Keywords
antibiotic-resistant; magnetic nanoparticles; pathogenic bacteria; photokilling; titania
Funding
- National Science Council of Taiwan
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Aims: We demonstrate a photokilling approach for pathogenic bacteria using magnetic nanoparticles as photokilling nanoprobes. Materials & methods: The nanoprobes are composed of iron oxide/titania (Fe3O4/TiO2) core/shell magnetic nanoparticles. The titanium layer on the magnetic nanoprobes plays two roles: as a photokilling agent and as an affinity substrate for pathogenic bacteria. The magnetic property of the nanoprobes allows the resultant nanoprobe-target species conjugates to be readily aggregated at a small spot under external magnetic field for conducting photokilling treatment. Therefore, damage to nontarget cells can be reduced. Results: The results show that Fe3O4/TiO2 core/shell magnetic nanoparticles do not only have the capacity to target pathogenic bacteria, including Gram-negative, Gram-positive and antibiotic-resistant bacteria, but they can also be used to effectively inhibit the cell growth of the bacteria (>99.9%) targeted by the magnetic nanoparticles under irradiation of a low-power UV lamp (lambda(max) similar to 306 nm, 0.412 mW/cm(2)) within 15 min. Conclusion: The potential application of this approach is in the treatment of cutaneous bacterial infections.
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