Journal
NANOMEDICINE
Volume 5, Issue 3, Pages 397-408Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/NNM.10.15
Keywords
blood brain barrier disruption; brain imaging; magnetic nanoparticles; NMR contrast agent; NMR imaging; USPIO iron oxide
Funding
- Spanish Ministry ofScience and Innovation (MICINN)
- Spanish National Research Council [20082 01084]
- Spanish Ministry of Science and Innovation [NAN2004-08805-001-04, MAT2008-01489, CSD2007-00010, SAF2008-05512, MAT2006-03999, MAT200908667, CSD2006-00012, SAF2008-00471]
- Madrid [5-0505/MAT/0194, CCG08-CSIC/SAL-3451]
- Cataluna regional governments [2009SGR856]
- Instituto de Salud Carlos III [RD08/0075]
- European Union [LSHB-CT-2006-037639]
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Background & aim: Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. Material & method: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. Results: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
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