Journal
NANOMEDICINE
Volume 3, Issue 2, Pages 183-199Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/17435889.3.2.183
Keywords
bionanotechnology; carbon nanotubes; contact guidance; electrospinning; nanotopography; neural electrodes; neural prosthetics; neural tissue engineering; self-assembled nanofibers
Ask authors/readers for more resources
This review discusses the design of scaffolds having submicron and nanoscale features for neural-engineering applications. In particular, the goal is to create materials that can interface more intimately with individual neuronal cells, within both living tissues and in culture, by better mimicking the native extracellular environment. Scaffolds with nanoscale features have the potential to improve the specificity and accuracy of materials for a number of neural-engineering applications, ranging from neural probes for Parkinson's patients to guidance scaffolds for axonal regeneration in patients with traumatic nerve injuries. This review will highlight several techniques that are used to create nanostructured scaffolds, such as photolithography to create grooves for neurite guidance, electrospinning of fibrous matrices, self-assembly of 3D scaffolds from designer pepticles and fabrication of conductive nanoscale materials. Most importantly, this review focuses on the effects of incorporating nanoscale architectures into these materials on neuronal and glial cell growth and function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available