Journal
NANOMEDICINE
Volume 3, Issue 5, Pages 617-626Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/17435889.3.5.617
Keywords
cancer; gold nanoparticles; laser; photothermal therapy; photothermalysis; viability
Funding
- National Science Foundation [DMR 0552294]
- NIRT [CMMI 0506531]
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Background & aims: Gold nanoparticles are excellent photon-thermal energy converters. The purpose of this work was to investigate the influence of gold nanoparticles on the photothermalysis of A549 lung tumor cells. Materials & methods: A549 lung tumor cells were exposed to goat antihuman immunoglobulin (Ig)G-conjugated gold nanospheres (40 nm) and were then imaged under a dark-field microscope. The live cells were then subjected to photoirradiation using a 633-nm laser at different power levels. The viability of tumor cells under laser irradiation was monitored by confocal microscopy using a viability-assay kit. Results & discussion: The death rates of A549 lung tumor cells after gold nanoparticle exposure increased significantly under laser irradiation. The maximum initial cell death rate was observed at a laser power level of 3.75 mW, with the initial deactivation rate accelerated by a factor of 6.6 and a total loss of 92% of cell viability. Conclusion: This work demonstrated potential applications of gold nanospheres as both imaging probes and enhancing agents for photothermal therapy of cancer.
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