Journal
NANO TODAY
Volume 9, Issue 1, Pages 10-16Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2014.02.004
Keywords
Nanomaterials; Free antibody production; Long-circulating; Polymers
Categories
Funding
- Defence Threat Reduction Agency [HDTRA-1-13-1-0044]
- National Science Foundation [DMR 1307375]
- Office of Naval Research [N000140910137]
- University of Washington
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1307375] Funding Source: National Science Foundation
Ask authors/readers for more resources
Poly(ethylene glycol) (PEG) has been incorporated into nanoparticles (NPs) to improve circulation time from systemic circulation for decades with limited success. Recent studies have shown that PEG induces the production of PEG-specific antibodies after repeated injections. Here, we demonstrate zwitterionic poly(carboxybetaine) (PCB)-based nanomaterials with no production of polymer-specific antibodies, while PEG-coated NPs generated PEG-specific antibodies. Furthermore, PCB-coated NPs exhibited prolonged circulation time and showed little change between the first and second doses (t(1/2) = 55.8 and 55.6 h), with no accelerated blood clearance suffered by PEG-coated NPs (t(1/2) drops from 8.7 to 5.2 h). These findings are significant advances toward solving the long-standing clinical challenge of developing nanomaterials that are able to resist both immune response and immediate bodily clearance. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available