Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted and controlled anticancer drug delivery due to their excellent biocompatibility, prolonged circulation time, enhanced accumulation in tumor, and in vivo degradability. Notably, several micellar anticancer drugs, with clear advantages of decreased side effects and improved drug tolerance, have advanced to different phases of clinical trials. The therapeutic outcomes are, however, far from optimal, due to issues of low in vivo stability, poor tumor penetration, inefficient cellular uptake, slow intracellular drug release, etc. This review high-lights recent developments in functional biodegradable micelles for safe and efficient cancer chemotherapy. (c) 2012 Elsevier Ltd. All rights reserved.