Journal
NANO TODAY
Volume 7, Issue 5, Pages 404-413Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2012.08.001
Keywords
Polyethylene glycol; Zwitterions; Non-fouling; Protein conjugation; Liposome; Drug delivery
Categories
Funding
- Office of Naval Research [N000140910137, N000141010600, N000141210441]
- National Science Foundation [DMR-1005699, CBET 0854298]
- Defense Threat Reduction Agency [HDTRA1-10-1-0074]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1005699] Funding Source: National Science Foundation
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This review compares two types of non-fouling polymers, the widely used nonionic poly(ethylene glycol) (PEG) and the recently established zwitterionic poly(carboxybetaine) (PCB), for their use in creating stealth nanoparticles (NPs) for drug delivery and protein protection. While both types of polymers exhibit reasonable non-fouling properties, such as good protein and colloidal stability and extended blood circulation time in vivo, amphiphilic PEG has negative effects on proteins and NPs due to its hydrophobic nature, including reduced protein bioactivity, instability of assembled NPs, and lipid bilayer destabilization. These problems can be overcome by super-hydrophilic PCB. (c) 2012 Elsevier Ltd. All rights reserved.
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