Journal
NANO TODAY
Volume 6, Issue 3, Pages 309-325Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2011.04.001
Keywords
Cell therapy; Cell surface bioengineering; Adoptive T cell therapy; Nanoparticles
Categories
Funding
- National Science Foundation through the MIT Center for Materials Science and Engineering [DMR-0819762]
- Dept. of Defense [W81XWH-10-1-0290]
- NIH [CA140476, EB012352]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [819762] Funding Source: National Science Foundation
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Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells. (C) 2011 Elsevier Ltd. All rights reserved.
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