Journal
NANO TODAY
Volume 6, Issue 2, Pages 131-154Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2011.02.001
Keywords
Silicon nanowire; Field-effect transistor; Protein-protein interaction; DNA hybridization; Peptide-small molecule interaction; Biomarker detection; Three-dimensional; localized bioprobe
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Funding
- National Science Council of Taiwan [NSC 99-2627-M-002-001]
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Silicon nanowire field-effect transistors (SiNW-FETs) have recently drawn tremencous attention as a promising tool in biosensor design because of their ultrasensitivity, selectivity, and label-free and real-time detection capabilities. Here, we review the recently published literature that describes the device fabrication and biomedical applications of SiNW-FET sensors. For practical uses, SiNW-FETs can be delicately designed to be a reusable device via a reversible surface functionalization method. In the fields of biological research, SiNW-FETs are employed in the detections of proteins, DNA sequences, small molecules, cancer biomarkers, and viruses. The methods by which the SiNW-FET devices were integrated with these representative examples and advanced to virus infection diagnosis or early cancer detection will be discussed. In addition, the utilization of SiNW-FETs in recording the physiological responses from cells or tissues will also be reviewed. Finally, the novel design of a three dimensional (3D) nano-FET probe with kinked SiNWs for recording intracellular signals will be highlighted in this review. (C) 2011 Elsevier Ltd. All rights reserved.
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