Journal
NANO TODAY
Volume 6, Issue 6, Pages 552-563Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2011.10.003
Keywords
Two-photon activated-photodynamic therapy; Mesoporous silica nanoparticles; Energy transfer
Categories
Funding
- National Health Research Institutes of Taiwan [MED-099-PP-04, NM-099-PP-01]
- National Science Council of Taiwan [NSC 98-2221-E-400-001, NSC 99-2113-M-400-001-MY3]
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Two-photon activated-photodynamic therapy (TPA-PDT) allows for spatially selective treatment of cancers, and enhances the tissue penetration depth of incident light. The three dimensional (3D) interface energy transfers in hexagonal mesoporous silica nanoparticles (MSNs) can significantly enhance the photodynamic effect. By providing a well-defined mesoporous nanostructure, we established an efficient and controllable energy transfer mechanism via the facile modification of a two-photon antenna molecule and photosensitizer on different topological domains in the MSN. The cytotoxicity induced by the singlet oxygen, generated following relay of energy transfer, was demonstrated in both in vitro and in vivo breast cancer models. Therefore, our results contribute new insight to the highly efficient energy transfer within a single nanoparticle for two-photon activated PDT, worthwhile for studying its potential for development in clinical translation. (C) 2011 Elsevier Ltd. All rights reserved.
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