Journal
NANO TODAY
Volume 5, Issue 4, Pages 337-350Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2010.06.011
Keywords
Host-guest interaction; Cyclodextrin; Supramolecular chemistry; Self-assembly; Nano-assembly; Micelle; Vesicle; Drug delivery; Gene therapy; Medical imaging
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Funding
- NIH (NIDCR) [DE015384, DE017689]
- Third Military Medical University
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Supramolecular nano-structures assembled by polymeric amphiphiles have been intensively studied during the last two decades. Such nanocarriers may be engineered to possess on-demand bio-responsitivity for the prevention, diagnosis, and treatment of human diseases. The successful development of several nano-assembly-based polymer therapeutics further encouraged scientists to develop nano-vehicles to achieve controlled release, enhanced efficacy, improved specificity and reduced toxicity. Different from the abundant existing literatures on the hydrophobically or electrostatically driven self-assemblies and their therapeutic applications, this article reviews host guest interaction mediated nano-assemblies, especially those constructed using cyclodextrins as the host entities. The excellent biocompatibility, complexation capacity, and chemical-sensitivity of cyclodextrin make cyclodextrin-containing polymers attractive to construct host guest nano-assemblies. Such nanocarriers may be advantageous also because of the broad availability of cyclodextrins, their flexibility for structure/property modulation and their chemical-responsive characteristics. (C) 2010 Elsevier Ltd. All rights reserved.
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