Journal
NANO TODAY
Volume 4, Issue 4, Pages 302-317Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2009.06.001
Keywords
Self-assembly; Polymer nanostructures; Drug delivery; Protein delivery; Gene delivery; Cancer therapy
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Funding
- Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore
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Nanostructures self-assembled from amphiphilic functional copolymers have emerged as safe and efficient nanocarriers for delivery of anticancer therapeutics. The development of this class of nanostructures has advanced from basic spherical micelles for delivery of small molecular hydrophobic drugs to a more complex functional structure for more efficient delivery of a wide range of therapeutics including small molecular drugs, macromolecular proteins and genes. This review describes physiological barriers for delivery of therapeutics, summarizes various approaches to overcome these barriers, and discusses the challenges in the current approaches for cancer therapy and perspectives for future solutions. (C) 2009 Elsevier Ltd. All rights reserved.
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