Journal
NANO TODAY
Volume 4, Issue 5, Pages 399-413Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2009.07.001
Keywords
Molecular imaging; Nanoparticle; Internal radiotherapy; Cancer; Positron emission tomography (PET); Single-photon emission computed tomography (SPECT)
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Funding
- NCRR NIH HHS [UL1 RR025011-01, UL1 RR025011] Funding Source: Medline
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This review summarizes the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and internal radiotherapy applications targeting cancer. With the capacity to provide enormous flexibility, radiolabeled nanoparticles have the potential to profoundly impact disease diagnosis and patient management in the near future. Currently, the major challenges facing the research on radiolabeled nanoparticles are desirable (tumor) targeting efficacy, robust chemistry for both radionuclide encapsulation/incorporation and targeting ligand conjugation, favorable safety profile, as well as certain commercial and regulatory hurdles. (C) 2009 Elsevier Ltd. All rights reserved.
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