Journal
NANO RESEARCH
Volume 5, Issue 4, Pages 272-282Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-012-0207-4
Keywords
Fe3O4; Au; electrochemical immunosensor; surface-enhanced Raman scattering
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Funding
- National Natural Science Foundation of China (NSFC) [60976014, 60976004, 11074075]
- Scientific and Technology Committee of Shanghai [09DJ1400200]
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A facile method of synthesizing Fe3O4-Au hybrid nanoparticles is reported utilizing the multifunctional nature of polyethyleneimine (PEI). An abundance of 5 nm gold nanoparticles were attached to 50 nm Fe3O4 nanoparticles via the covalent binding between the -NH2 groups of the PEI and Au nanoparticles, as well as the electrostatic interaction between the negatively charged citrate-coated Au nanoparticles and the positively charged PEI-coated Fe3O4 nanoparticles. The as-prepared Fe3O4-Au hybrid nanoparticles, which combine the merits of magnetic materials and gold, were successfully employed for the first time in the dual-mode detection of carcinoembryonic antigen (CEA) via electrochemical and surface-enhanced Raman scattering (SERS) methods. Both methods make clever use of Fe3O4-Au nanoparticles and can accurately verify the presence of antigens. In particular, the electrochemical immunosensor detection displays a wide linear range (0.01-10 ng/mL) of response with a low detection limit (10 pg/mL), while the SERS method responds to even lower antigen concentrations with a wider detection range. The Fe3O4-Au hybrid nanoparticles therefore exhibit great potential for biomedical applications.
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