Journal
NANO RESEARCH
Volume 1, Issue 6, Pages 457-464Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-008-8048-x
Keywords
Quantum dots; InAs; near-infrared (NIR); toxicity
Categories
Funding
- National Cancer Institute (NCI) [R21 CA121842, P50 CA114747, U54 CA119367]
- National Institute of Health [R43 EB005072]
- National Science Foundation [CHE-0554812]
- NATIONAL CANCER INSTITUTE [R21CA121842, U54CA119367, P50CA114747] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R43EB005072] Funding Source: NIH RePORTER
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High quality InAs/InP/ZnSe core/shell/shell quantum dots have been grown by a one-pot approach. This engineered quantum dots with unique near-infrared (NIR) fluorescence, possessing outstanding optical properties, and the biocompatibility desired for in vivo applications. The resulting quantum dots have significantly lower intrinsic toxicity compared to NIR emissive dots containing elements such as cadmium, mercury, or lead. Also, these newly developed ultrasmall non-Cd containing and NIR-emitting quantum dots showed significantly improved circulation half-life and minimal reticuloendothelial system (RES) uptake.
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