Journal
NANO LETTERS
Volume 18, Issue 9, Pages 6100-6105Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.8b03163
Keywords
3D nanostructures; cell penetration; electroporation; cell membrane deformation; cell cross-section; biointerface
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Funding
- European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant [616213]
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The dynamic interface between the cellular membrane and 3D nanostructures determines biological processes and guides the design of novel biomedical devices. Despite the fact that recent advancements in the fabrication of artificial biointerfaces have yielded an enhanced understanding of this interface, there remain open questions on how the cellular membrane reacts and behaves in the presence of sharp objects on the nanoscale. Here we provide a multifaceted characterization of the cellular membrane's mechanical stability when closely interacting with high-aspect-ratio 3D vertical nanostructures, providing strong evidence that vertical nanostructures spontaneously penetrate the cellular membrane to form a steady intracellular coupling only in rare cases and under specific conditions. The cell membrane is able to conform tightly over the majority of structures with various shapes while maintaining its integrity.
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